HSR-609

HSR-609 is an orally active amphoteric antiallergic agent. HSR-609 has a high affinity for histamine H1-receptor in the guinea pig cerebral cortex. HSR-609 inhibits allergic airway hyperresponsiveness to Acetylcholine. HSR-609 shows poor ability to penetrate into the CNS in mice and guinea pigs[1][2].

Product Specifications

CAS Number

[161522-25-4]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/hsr-609.html

Smiles

O=C(O)CCN1CC/C(CC1)=C2C3=CC=C(F)C=C3OCC4=CC=CN=C4\2

Molecular Formula

C21H21FN2O3

Molecular Weight

368.40

References & Citations

[1]M Kakiuchi, et al. Studies on the novel antiallergic agent HSR-609: its penetration into the central nervous system in mice and guinea pigs and its selectivity for the histamine H1-receptor. Jpn J Pharmacol. 1997 Apr;73 (4) :291-8.|[2]K Musoh, et al. Effect of a novel anti-allergic agent, HSR-609, on antigen-induced airway hyperresponsiveness in mice. Pharmacology. 2000 Aug;61 (2) :70-7.