Lobetyolin
Product Specifications
UNSPSC Description
Lobetyolin, a bioactive compound, is derived from Codonopsis pilosula. Lobetyolin has anti-inflammatory, anti-oxidative and xanthine oxidase inhibiting activities. Lobetyolin also induces the apoptosis via the inhibition of ASCT2-mediated glutamine metabolism[1][2]. Lobetyolin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Target Antigen
Apoptosis; Xanthine Oxidase
Type
Natural Products
Related Pathways
Apoptosis;Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/Lobetyolin.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
Smiles
O[C@H](C#CC#C/C=C/C)[C@@H](/C=C/CCCO)O[C@@H]([C@@H]([C@H]1O)O)O[C@@H]([C@H]1O)CO
Molecular Weight
396.43
References & Citations
[1]Yoon YP, et al. Effects of Lobetyolin, Lobetyol and Methyl linoleate on Secretion, Production and Gene Expression of MUC5AC Mucin from Airway Epithelial Cells. Tuberc Respir Dis (Seoul). 2014 Nov;77(5):203-8.|[2]He W, et, al. Lobetyolin induces apoptosis of colon cancer cells by inhibiting glutamine metabolism. J Cell Mol Med. 2020 Mar;24(6):3359-3369.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N0327/Lobetyolin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N0327/Lobetyolin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
129277-38-9
Available Sizes
Curated Selection
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