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FITC-Labeled VEGFR-2, Human (HEK293, His)

VEGFR-2 is a tyrosine-protein kinase of the cell surface receptors of VEGFA, VEGFC, and VEGFD that mediates activation of the MAPK1/ERK2, MAPK3/ERK1, and MAP kinase signaling pathways, as well as the AKT1 signaling pathway. VEGFR-2 can promote the proliferation, survival, migration and differentiation of endothelial cells. Overexpression of VEGFR-2 is associated with the development of tumors. FITC-Labeled VEGFR-2 Protein, Human (HEK293, His) is the recombinant human-derived FITC-Labeled VEGFR-2 protein, expressed by HEK293 , with His labeled tag.

Product Specifications

Product Name Alternative

FITC-Labeled VEGFR-2 Protein, Human (HEK293, His), Human, HEK293

UNSPSC

12352202

Type

Reference compound

Assay Protocol

https://www.medchemexpress.com/cytokines/fitc-labeled-vegfr-2-protein-human-hek293-his.html

Molecular Formula

3791 (Gene_ID) P35968-1 (A20-E764) (Accession)

Molecular Weight

Approximately 110-120 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

References & Citations

[1]Dougher M, et al. Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization. Oncogene. 1999 Feb 25;18 (8) :1619-27.|[2]McTigue et al. Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis. Structure. 1999 Mar 15;7 (3) :319-30.|[3]Holmqvist K, et al. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem. 2004 May 21;279 (21) :22267-75.|[4]Kroll J, et al. VEGF-A induces expression of eNOS and iNOS in endothelial cells via VEGF receptor-2 (KDR) . Biochem Biophys Res Commun. 1998 Nov 27;252 (3) :743-6.|[5]Rho SB, et al. Programmed cell death 6 (PDCD6) inhibits angiogenesis through PI3K/mTOR/p70S6K pathway by interacting of VEGFR-2. Cell Signal. 2012 Jan;24 (1) :131-9.|[6]Guo S, et al. Vascular endothelial growth factor receptor-2 in breast cancer. Biochim Biophys Acta. 2010 Aug;1806 (1) :108-21.

Shipping Conditions

Room temperature in continental US; may vary elsewhere.

Scientific Category

Recombinant Proteins

Frequently Asked Questions

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