CMLD-2

CMLD-2, an inhibitor of HuR-ARE interaction, competitively binds HuR protein disrupting its interaction with adenine-uridine rich elements (ARE) -containing mRNAs (Ki=350 nM) . CMLD-2 induces apoptosis exhibits antitumor activity in different cancer cells as colon, pancreatic, thyroid and lung cancer cell lines. Hu antigen R (HuR) is an RNA binding protein, can regulate target mRNAs stability and translation[1][2].

Product Specifications

CAS Number

[958843-91-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

HuR

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cmld-2.html

Purity

98.66

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=CC=C2)C3=C(OC)C=C(OC)C(C(C4=CC=C(OC)C=C4)CC(N5CCCC5)=O)=C3O1

Molecular Formula

C31H31NO6

Molecular Weight

513.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu X, et, al. Identification and validation of novel small molecule disruptors of HuR-mRNA interaction. ACS Chem Biol. 2015 Jun 19;10 (6) :1476-84.|[2]Allegri , et, al. The HuR CMLD-2 inhibitor exhibits antitumor effects via MAD2 downregulation in thyroid cancer cells. Sci Rep. 2019 May 14;9 (1) :7374.|[3]Muralidharan R, et, al. HuR-targeted small molecule inhibitor exhibits cytotoxicity towards human lung cancer cells. Sci Rep. 2017 Aug 30;7 (1) :9694.