Floxuridine

Floxuridine (5-Fluorouracil 2'-deoxyriboside) is a pyrimidine analog and known as an oncology antimetabolite. Floxuridine inhibits Poly (ADP-Ribose) polymerase and induces DNA damage by activating the ATM and ATR checkpoint signaling pathways in vitro. Floxuridine is a extreamly potent inhibitor for S. aureus infection and induces cell apoptosis[1][2]. Floxuridine has antiviral effects against HSV and CMV[3].

Product Specifications

CAS Number

[50-91-9]

Product Name Alternative

5-Fluorouracil 2'-deoxyriboside

UNSPSC

12352005

Hazard Statement

H301

Target

Apoptosis; Bacterial; CMV; DNA/RNA Synthesis; HSV; Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/floxuridine.html

Purity

99.97

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : ≥ 50 mg/mL

Smiles

OC[C@@H]1[C@@H](O)C[C@H](N2C(NC(C(F)=C2)=O)=O)O1

Molecular Formula

C9H11FN2O5

Molecular Weight

246.19

Precautions

H301

References & Citations

[1]Huehls AM, et al. Poly (ADP-Ribose) polymerase inhibition synergizes with 5-fluorodeoxyuridine but not 5-fluorouracil in ovarian cancer cells.Cancer Res. 2011 Jul 15;71 (14) :4944-54.|[2]Yeo WS, et al. The FDA-approved anti-cancer drugs, streptozotocin and floxuridine, reduce the virulence of Staphylococcus aureus.Sci Rep. 2018 Feb 6;8 (1) :2521.|[3]Langman J, et al. Floxuridine and its influence on postnatal cerebellar development. Pediatr Res. 1972 Oct;6 (10) :758-64.