Recombinant Human Insulin-like growth factor-binding protein 3 receptor (TMEM219), partial

Product Specifications

Product Name Alternative

(IGFBP-3R) (Transmembrane protein 219)

Abbreviation

Recombinant Human TMEM219 protein, partial

Gene Name

TMEM219

UniProt

Q86XT9

Expression Region

39-204aa

Organism

Homo sapiens (Human)

Target Sequence

SFLLTHRTGLRSPDIPQDWVSFLRSFGQLTLCPRNGTVTGKWRGSHVVGLLTTLNFGDGPDRNKTRTFQATVLGSQMGLKGSSAGQLVLITARVTTERTAGTCLYFSAVPGILPSSQPPISCSEEGAGNATLSPRMGEECVSVWSHEGLVLTKLLTSEELALCGSR

Tag

N-terminal 6xHis-tagged

Type

In Stock Protein

Source

E.coli

Field of Research

Cardiovascular

Relevance

Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding.

Endotoxin

Not test

Purity

Greater than 90% as determined by SDS-PAGE.

Activity

Not Test

Form

Liquid or Lyophilized powder

Buffer

If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Molecular Weight

23.7 kDa

References & Citations

"IL-13Ralpha2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses." Lee C.M., He C.H., Nour A.M., Zhou Y., Ma B., Park J.W., Kim K.H., Dela Cruz C., Sharma L., Nasr M.L., Modis Y., Lee C.G., Elias J.A. Nat Commun 7:12752-12752 (2016)

Storage Conditions

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.