ETP-45658

ETP-45658 is a potent PI3K inhibitor, with IC50s of 22.0 nM, 39.8 nM, 129.0 nM and 717.3 nM for PI3Kα, PI3Kδ, PI3Kβ and PI3Kγ, respectively. ETP-45658 also can inhibit DNA-PK (IC50=70.6 nM) and mTOR (IC50=152.0 nM) . ETP-45658 can be used for the research of cancer[1][2].

Product Specifications

CAS Number

[1198357-79-7]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

DNA-PK; mTOR; PI3K

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/etp-45658.html

Concentration

10mM

Purity

98.97

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

CN1C2=NC(C3=CC(O)=CC=C3)=NC(N4CCOCC4)=C2C=N1

Molecular Formula

C16H17N5O2

Molecular Weight

311.34

Precautions

H315, H319

References & Citations

[1]Link W, et, al. Chemical interrogation of FOXO3a nuclear translocation identifies potent and selective inhibitors of phosphoinositide 3-kinases. J Biol Chem. 2009 Oct 9;284 (41) :28392-28400.|[2]Hill R, et, al. A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes. Breast Cancer Res. 2014 Dec 9;16 (6) :482.