IWP L6

IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC50 of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish[1].

Product Specifications

CAS Number

[1427782-89-5]

Product Name Alternative

Porcn Inhibitor III

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Porcupine

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/IWP-L6.html

Purity

99.50

Solubility

DMSO : 22.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O

Molecular Formula

C25H20N4O2S2

Molecular Weight

472.58

Precautions

H302, H315, H319, H335

References & Citations

[1]Wang X, et al. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56 (6) :2700-4.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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