IWP L6
IWP L6 (Porcn Inhibitor III) is a Porcupine (Porcn) inhibitor with an EC50 of 0.5 nM. IWP L6 disrupts well-established Wnt-dependent developmental processes of embryonic and juvenile zebrafish[1].
Product Specifications
CAS Number
[1427782-89-5]
Product Name Alternative
Porcn Inhibitor III
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Porcupine
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/IWP-L6.html
Purity
99.50
Solubility
DMSO : 22.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=NC=C(C2=CC=CC=C2)C=C1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O
Molecular Formula
C25H20N4O2S2
Molecular Weight
472.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Wang X, et al. The development of highly potent inhibitors for porcupine. J Med Chem. 2013 Mar 28;56 (6) :2700-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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