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PD 198306

PD 198306 is a selective MAPK/ERK-kinase (MEK) inhibitor. PD 198306 results in an observable reduction in the Streptozocin induced increase in the level of active ERK1 and 2. Antihyperalgesic effects[1].

Product Specifications

CAS Number

212631-61-3

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pd-198306.html

Purity

99.75

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

O=C(NOCC1CC1)C(C=C(F)C(F)=C2F)=C2NC3=C(C=C(I)C=C3)C

Molecular Formula

C18H16F3IN2O2

Molecular Weight

476.23

Precautions

H228, H315, H319

References & Citations

[1]A Ciruela, et al. Identification of MEK1 as a novel target for the treatment of neuropathic pain. Br J Pharmacol. 2003 Mar;138 (5) :751-6. |[2]Benoit Besson, et al. Kinome-Wide RNA Interference Screening Identifies Mitogen-Activated Protein Kinases and Phosphatidylinositol Metabolism as Key Factors for Rabies Virus Infection. mSphere. 2019 May 22;4 (3) :e00047-19.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MEK

Available Sizes

Frequently Asked Questions

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