DSR-6434

DSR-6434 is a potent and selective Toll-like receptor 7 (TLR7) agonist, with EC50s of 7.2 nM and 4.6 nM for human and mice TLR7, respectively. DSR-6434 has a strong antitumor effect[1][2].

Product Specifications

CAS Number

[1059070-10-8]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dsr-6434.html

Concentration

10mM

Purity

99.32

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1N(C2=NC(NCCCC)=NC(N)=C2N1)CC3=CN=C(OCCN(C)C)C=C3

Molecular Formula

C19H28N8O2

Molecular Weight

400.48

Precautions

H315, H319, H335

References & Citations

[1]Nakamura T, et al. Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorg Med Chem Lett. 2013 Feb 1;23 (3) :669-72.|[2]Adlard AL, et al. A novel systemically administered Toll-like receptor 7 agonist potentiates the effect of ionizing radiation in murine solid tumor models. Int J Cancer. 2014 Aug 15;135 (4) :820-9.