SIRT5 inhibitor 3
SIRT5 inhibitor 3 (compound 46) is a potent and competitive SIRT5 inhibitor with an IC50 value of 5.9 μM. SIRT5 inhibitor 3 can inhibit SIRT5 desuccinylation. SIRT5 inhibitor 3 can be used for researching cancer and neurodegenerative diseases[1].
Product Specifications
CAS Number
[2128651-12-5]
UNSPSC
12352005
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sirt5-inhibitor-3.html
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
N#CC1=CC=C(C=C1F)NC(/C(C#N)=C/C2=CC=C(O2)C3=CC=C(C=C3)C(O)=O)=O
Molecular Formula
C22H12FN3O4
Molecular Weight
401.35
References & Citations
[1]Wang Y, et al. Overview of SIRT5 as a potential therapeutic target: Structure, function and inhibitors. Eur J Med Chem. 2022;236:114363.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIRT5
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
