Losartan (Standard)

Losartan (Standard) is the analytical standard of Losartan. This product is intended for research and analytical applications. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.

Product Specifications

CAS Number

[114798-26-4]

Product Name Alternative

DuP-753 (Standard)

UNSPSC

12352005

Hazard Statement

H302-H319-H360

Target

Angiotensin Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Others

Field of Research

Cardiovascular Disease; Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/losartan-standard.html

Purity

90.000000

Smiles

OCC1=C(Cl)N=C(CCCC)N1CC2=CC=C(C3=CC=CC=C3C4=NNN=N4)C=C2

Molecular Formula

C22H23ClN6O

Molecular Weight

422.91

Precautions

P264-P270-P280-P305+P351+P338-P330-P405-P501

References & Citations

[1]Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103 (6) : p. 904-12.|[2]Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.|[3]Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126 (1) : p. 124-31.|[4]Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312 (5770) : p. 117-21.|[5]Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26 (2) : p. 233-40.