N2-Acetylguanine

N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an Kd value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent[1].

Product Specifications

CAS Number

[19962-37-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

DNA/RNA Synthesis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/n2-acetylguanine.html

Purity

99.92

Solubility

DMSO : 3.57 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

O=C1N=C(NC2=C1NC=N2)NC(C)=O

Molecular Formula

C7H7N5O2

Molecular Weight

193.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Matyjasik MM, et al. High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch. Molecules. 2020 May 13;25 (10) :2295.