Pim-1 kinase inhibitor 11
Pim-1 kinase inhibitor 11 (10f) is a PIM-1 inhibitor, with an IC50 of 0.18 μM. Pim-1 kinase inhibitor 11 (10f) exhibits anticancer activity. Pim-1 kinase inhibitor 11 (10f) induces apoptosis and arrests cell cycle progression[1].
Product Specifications
UNSPSC
12352005
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pim-1-kinase-inhibitor-11.html
Smiles
COC(C=C1)=CC=C1C2=CC=NC3=C2C(C4=CNC5=C4C=CC=C5)=NN3C6=CC=CC=C6
Molecular Formula
C27H20N4O
Molecular Weight
416.47
References & Citations
[1]Wagdy M Eldehna, et al. Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights. Bioorg Chem. 2024 Sep 6:153:107804.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1
Frequently Asked Questions
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