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Pim-1 kinase inhibitor 11

Pim-1 kinase inhibitor 11 (10f) is a PIM-1 inhibitor, with an IC50 of 0.18 μM. Pim-1 kinase inhibitor 11 (10f) exhibits anticancer activity. Pim-1 kinase inhibitor 11 (10f) induces apoptosis and arrests cell cycle progression[1].

Product Specifications

UNSPSC

12352005

Target

Pim

Type

Reference compound

Related Pathways

JAK/STAT Signaling

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pim-1-kinase-inhibitor-11.html

Smiles

COC(C=C1)=CC=C1C2=CC=NC3=C2C(C4=CNC5=C4C=CC=C5)=NN3C6=CC=CC=C6

Molecular Formula

C27H20N4O

Molecular Weight

416.47

References & Citations

[1]Wagdy M Eldehna, et al. Identification of indole-grafted pyrazolopyrimidine and pyrazolopyridine derivatives as new anti-cancer agents: Synthesis, biological assessments, and molecular modeling insights. Bioorg Chem. 2024 Sep 6:153:107804.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PIM1

Frequently Asked Questions

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