Ɑ-Hydroxy-ω-Tritylmercaptopropanamido PEG

The hydroxy group on one side of this PEG crosslinker is able to undergo esterification reactions with acids for reversible pegylation. It also enables further derivatization or replacement with other reactive functional groups. PEG tritylthio derivatives feature a protected thiol at on chain end. Trityl groups are easily removed with acid. Pure TFA or TFA/DCM mixtures cleave trityl from thiols quantitatively.