Diacylglycerol kinase, alpha 80kDa Adenovirus (Ad-DGKa)

The accumulation of diacylglycerol in the nucleus is important for the regulation of cell growth and differentiation. Diacylglycerol kinases (DGKs) convert diacylglycerol to phosphatidic acid, thereby terminating diacylglycerol signaling, which results in the reduction of protein kinase C activity and cell cycle progression of T-lymphocytes. Diacylglycerol kinases are divided into five subtypes, Type I - Type V. DGK-α, DGK-Î2 and DGK-Î3 are Type I DGKs; DGK-Î ́ and DGK-η are Type II DGKs; DGK-Îμ is a Type III DGK; DGK-ζ is a Type IV DGK; and DGK-Î ̧ is a Type V DGK.