S-phase kinase-associated protein 2 (p45) Adenovirus (Ad-SKP2)

Cyclin A-Cdk2 kinase activity is essential for progression of the cell through S phase. Skp1 p19 and Skp2 p45 are elements of the cyclin A-Cdk2 S phase kinase. The binding of p19 to cyclin A-Cdk2 is p45-dependent, and levels of p45 are substantially increased in transformed cells. Thus, the modulation of Skp2 p45 expression may result in changes in cell cycle control that contribute to the process of cell transformation.