Four and a half LIM domains 2 Adenovirus (Ad-FHL2)

The Four-and-a-Half-LIM domain (FHL) proteins include FHL-1 (SLIM-1), FHL-2 (SLIM-3), FHL-3 (SLIM-2) and FHL-4. The signature ˆ ̧half-domainˆ ̧, a single zinc finger domain located in the N-terminal region, differentiates FHLs from other LIM-only proteins, which possess even numbered zinc fingers. Specific combinations of FHL proteins elicit selective activation of both CREB and CREM.