F-box only protein 32 Adenovirus (Ad-Fbox32)

MuRF1 (Muscle specific ring finger protein 1) is a nuclear protein that interacts with SMT3b and the large myofibrillar protein titin. MaFbx (Muscle atrophy F-box protein) recognizes and promotes ubiquitination and degradation of phosphorylated proteins during skeletal muscle atrophy. MaFbx or MuRF1 are resistant to atrophy and are therefore potential drug targets for muscle atrophy treatment. Both genes encode ubiquitin ligases and are muscle specific.