STAT3 interacting protein 1 Adenovirus (Ad-STAT3IP)

Genetic and biochemical studies have led to the identification of the Stat3-Interacting Protein STATIP1. The preferential association of STATIP1 with inactive (i.e., unphosphorylated) Stat3 suggests that it may contribute to the regulation of Stat3 activation. Overexpression of the Stat3-binding domain of STATIP1 blocks Stat3 activation, nuclear translocation, and Stat3-dependent induction of a reporter gene.