Early growth response 2 (Krox-20 homolog, Drosophila) Adenovirus (Ad-EGR2)

Several immediate early response genes are transiently activated in serum- or growth factor-stimulated cells. The early growth response genes encode nuclear proteins Egr-1 (NGFI-A), Egr-2 (Krox20), Egr-3 and Egr-4 (NGFI-C), which contain zinc finger DNA-binding domains closely resembling those of the transcription factor Sp1. The Egr proteins function in transcription regulatory activities surrounding cellular growth, differentiation and function. Wilmsˆ ̧ tumor nuclear protein (WT) is an anti-oncogene structurally related to the Egr family.