Platelet-derived growth factor receptor, beta polypeptide Adenovirus (Ad-PDGF-R (beta) )

The platelet derived growth factor receptor (PDGFR) family comprises PDGFR- (alpha) and PDGFR- (beta), which are structurally related and endowed with protein tyrosine kinase domains. These receptors bind the three PDGF ligand isoforms with different affinities. PDGFR- (alpha) can bind to both A and B subunits of PDGF, while PDGFR- (beta) can only bind the B subunit. Chromosomal translocation of the PDGFR-beta gene is linked with chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.