Caspase recruitment domain family, member 4 Adenovirus (Ad-NOD1)

The mammalian homologs of the Ced-4 proteins, Apaf-1 (Ced-4), Nod1 (CARD4) and Nod2 contain a caspase recruitment domain (CARD) and a putative nucleotide binding domain, signified by a consensus Walker's A box (P-loop) and B box (Mg2+-binding site) . Nod1 contains a putative regulatory domain and multiple leucine-rich repeats. Nod1 is a member of a growing family of intracellular proteins that share structural homology to the apoptosis regulator Apaf-1. Nod2 comprises two N-terminal CARDs, a nucleotide-binding domain, and multiple C-terminal leucine-rich repeats. Mutations in Nod2 confer susceptibility to Crohn disease, a chronic inflammatory bowel disorder.