Chemokine (C-C motif) ligand 2 Adenovirus (Ad-MCP-1)

Chemokines are members of a superfamily of inducible, secreted, pro-inflammatory cytokines. Members of the chemokine family exhibit 20 to 50% homology in their predicted amino acid sequences and are divided into four subfamilies. In the C-X-C or alpha subfamily, the first two of four cysteine residues are separated by a single amino acid. In the subfamily designated C-C or beta, the first two cysteines are adjacent. C subfamily members, also designated gamma chemokines, lack the first and third cysteine residues of the conserved motif. Chemokines in these three subfamilies are small, secreted proteins with molecular weights ranging from 7-15 kDa. Fractalkine is a 373 amino acid protein that contains a novel C-X3-C motif in which the first two cysteines are separated by three amino acid residues.