APC Adenovirus (Ad-CBR)
Adenomatous polyposis coli gene (APC) is a tumor suppressor gene located on chromosome 5q2. It is inactivated in most colorectal tumors. APC is a cytoplasmic protein that can bind to and promote the degradation of b-catenin. In most colorectal tumors, APC is inactivated. This increases the interaction between b-catenin and Tcf family of transcription factors, leading to increase transcription of genes such as c-Myc. This adenovirus contains APC mini-me fragment. Shih IM., et al., Cancer Res. 2000 Mar 15;60 (6) :1671-6.
Product Specifications
Product Name Alternative
APC Adenovirus
UNSPSC
41106621
HS Code
3822190000
Type
Pre-Made
Shipping Conditions
Dry Ice
Storage Conditions
-80C
Shelf Life
12 Months
Short Name
Ad-CBR
Viral Backbone
Human Adenovirus Type5 (dE1/E3)
Reporter
EGFP
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Ttiter
1x10^10 PFU/ml
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