Src Adenovirus (Ad-CMV-Src)

Several protein tyrosine kinases (Src, Fyn, Lyn, Yes, Lck, Hck, etc) have been identified within the Src gene family. On the basis of their associations with specific cell surface receptors, Src gene family members play critical roles in various signal transduction pathways.Src is regulated by tyrosine phosphorylation at two sites with opposite effects. Phosphorylation of Tyr 416 in the activation loop of the kinase domain upregulates the enzyme; Phosphorylation of Tyr 527 in the C-terminal by CSK inhibits the enzyme activity.This adenovirus has a Src activating and signaling molecule.