IFN-gamma; Adenovirus (Ad-CMV-IFN-gamma)

Interferon-gamma (IFN-Î3), also known as Type II interferon or immune interferon, is a cytokine produced primarily by T-lymphocytes and natural killer cells. The protein shares no significant homology with IFN-Î2 or the various IFN-α family proteins. IFN-Î3 was originally characterized based on its antiviral activities. The protein also exerts anti-proliferative, immuno-regulatory and pro-inflammatory activities and is thus important in host defense mechanisms. IFN-Î3 exerts its biological activities by binding to specific cell surface receptors with high-affinity binding sites.