TNFRSF11A Protein (C-human IgG1-Fc, Human)

Product Specifications

Abbreviation

TNFRSF11A

Synonyms

CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCE-R, TRANCER

Host

HEK 293

Tag

C-human IgG1-Fc

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

≥ 90 % as determined by SDS-PAGE. ≥ 85 % as determined by SEC-HPLC.

Bioactivity

Measured by its ability to inhibit TRANCE-induced osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 4-40 ng/mL in the presence of 10 ng/mL of TRANCE.

Function

Met1-Pro212

Molecular Weight

The recombinant human TNFRSF11A/Fc comprises 421 amino acids and has a predicted molecular mass of 46.8 kDa. The apparent molecular mass of the protein is approximately 53.3 kDa in SDS-PAGE under reducing conditions.