TGFBR1 Protein (C-human IgG1-Fc & His, Human)

Product Specifications

Abbreviation

TGFBR1

Synonyms

AAT5, ACVRLK4, ALK-5, ALK5, ESS1, LDS1, LDS1A, LDS2A, MSSE, SKR4, tbetaR-I, TBR-i, TBRI, TGFR-1

Host

HEK 293

Tag

C-human IgG1-Fc & His

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 85 % as determined by SDS-PAGE

Bioactivity

1. Measured by its binding ability in a functional ELISA . Immobilized mouse CD105 at 10 μg/ml (100 μl/well) can bind human TGFRB1 with a linear range of 6.4-800 ng/ml . 2. Measured by its ability to bind human CD105 in a functional ELISA .

Function

Met1-Glu125

Molecular Weight

The recombinant human TGFBR1/Fc is a disulfide-linked homodimer. The reduced monomer consists of 340 amino acids and has a predicted molecular mass of 38.1 kDa. As a result of glycosylation, the apparent molecular mass of rh TGFBR1/Fc monomer is approximately 45-50 kDa in SDS-PAGE under reducing conditions, with ~10% free Fc fragments.