NTRK1 Protein (N-His, Human)

Product Specifications

Abbreviation

NTRK1

Synonyms

MTC, p140-TrkA, TRK, Trk-A, TRK1, TRKA

Host

HEK 293

Tag

N-His

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

≥ 95 % as determined by SDS-PAGE. ≥ 95 % as determined by SEC-HPLC.

Bioactivity

Measured by its ability to inhibit NGF-induced proliferation of TF1 human erythroleukemic cells. The ED50 for this effect is typically 0.5-4 μg/ml in the presence of 10 ng/mL of human NGF.

Function

Pro194-Glu413

Molecular Weight

The recombinant human NTRK1 Ig-like C2-type 1 & 2 domains (aa 194-413) consists of 239 amino acids and has a predicted molecular mass of 26 kDa. As a result of glycosylation, it migrates as an approximately 45-50 kDa band in SDS-PAGE under reducing conditions.