NRG1 Protein (N-human IgG1-Fc, Human)

Product Specifications

Abbreviation

NRG1

Synonyms

ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF

Host

HEK 293

Tag

N-human IgG1-Fc

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 85 % as determined by SDS-PAGE

Bioactivity

1. Immobilized Human ERBB3 His (Cat: 10201-H08H) at 2 μg/ml (100 μl/well) can bind Human NRG1 Fc (Cat: 11609-H01H2), the EC50 of Human NRG1 Fc is 8-40 ng/mL. 2. Immobilized Rhesus ERBB3 His (Cat: 90043-K08H) at 2 μg/ml (100 μl/well) can bind Human NRG1 Fc (Cat: 11609-H01H2), the EC50 of Human NRG1 Fc is 20-80 ng/mL.

Function

Ser2-Lys246

Molecular Weight

The recombinant human NRG1 (aa2-246) /Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 505 amino acids and has a calculated molecular mass of 55.2 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of the protein is approximately 75 kDa due to glycosylation.