NRG1 Protein (C-human IgG1-Fc, Canine)

Product Specifications

Abbreviation

NRG1

Host

HEK 293

Tag

C-human IgG1-Fc

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 90 % as determined by SDS-PAGE

Bioactivity

Measured in a serum-free cell proliferation assay using MCF‐7 human breast cancer cells. The ED50 for this effect is typically 2-12 μg/mL.

Function

Ser19-Lys240

Molecular Weight

The recombinant canine NRG1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 460 amino acids and has a predicted molecular mass of 50.8 kDa. The apparent molecular mass of the protein is approximately 67 kDa in SDS-PAGE under reducing conditions.