LDLR Protein (C-human IgG1-Fc, Human)

Product Specifications

Abbreviation

LDLR

Synonyms

FH, FHC, FHCL1, LDLCQ2

Host

HEK 293

Tag

C-human IgG1-Fc

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Purity

≥ 95 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Bioactivity

1.Immobilized Recombinant Human LDLR/LDL Receptor Protein (Fc Tag) (Cat: 10231-H02H) at 2 μg/mL (100 μL/well) can bind Recombinant Human PCSK9 / NARC1 (D374Y) Protein (His Tag) (Cat: 29698-H08H1), the EC50 is 8-25 ng/mL (QC tested) . 2.Immobilized Recombinant Human LDLR/LDL Receptor Protein (Fc Tag) (Cat: 10231-H02H) at 2 μg/mL (100μL/well) can bind Recombinant Human PCSK9 / NARC1 (D374Y) Protein (His Tag) (Cat: 29698-H08H1), the EC50 is 15.8 ng/mL. Recombinant Human PCSK9 Protein (wild type, His Tag) (Cat: 29698-H08H2) is verified bind to Human LDLR/LDL Receptor Protein (Fc Tag) (Cat: 10231-H02H) wtih lower affinity (Routinely tested) .

Function

Ala22-Arg788

Molecular Weight

The recombinant Human LDLR comprises 1005 amino acids and has a predicted molecular mass of 111.51 kDa. It migrates as an approximately 147.6 and 121.3 kDa band in SDS-PAGE under reducing conditions.

Species

Human