IL25 Protein (N-human IgG1-Fc, Human)
Product Specifications
Abbreviation
IL25
Synonyms
IL-17E, IL-25, IL17E, UNQ3120/PRO10272
Host
HEK 293
Tag
N-human IgG1-Fc
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 95 % as determined by SDS-PAGE
Bioactivity
1. Measured by its binding ability in a functional ELISA. Immobilized human IL17BR-His (Cat:13091-H08H) at 10 μg/ml (100 μl/well) can bind human Fc-IL25 (Cat:10096-H01H), The EC50 of human Fc-IL25 (Cat:10096-H01H) is 1.7-4.2 μg/mL. 2. Measured by its ability to induce CXCL1/GROα secretion in HT29. The ED50 for this effect is 15-60 ng/mL.
Function
Tyr 33-Gly177
Molecular Weight
The recombinant human IL25/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 425 amino acids and predicts a molecular mass of 47.55 KDa. As a result of glycosylation, the apparent molecular mass of rh IL25/Fc monomer is approximately 50-60 KDa in SDS-PAGE under reducing conditions.
Species
Human
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