IL23R Protein (C-human IgG1-Fc, Human)

1.Immobilized Recombinant Human IL23R / IL23 Receptor Protein (ECD, Fc Tag) (Cat: 13840-H02H) at 2 μg/mL (100 μL/well) can bind Recombinant Human IL-23 Heterodimer Protein (His Tag) (Cat: CT139-H08H), the EC50 is 5-18 ng/mL. 2.Recombinant Human IL-23 Receptor Protein, hFc Tag (Cat. No. 13840-H02H) captured on Protein A chip can bind Recombinant Human IL-23 Protein, His Tag (Cat. No. CT048-H08H) with an affinity constant of 0.6961 nM as determined in an SPR assay (Biacore T200) (Routinely tested) . 3.Loaded Recombinant Human IL-23 Receptor Protein, hFc Tag (Cat. No. 13840-H02H) on proA Biosensor, can bind Recombinant Mouse IL-23 Protein, His Tag (Cat. No. CT140-M08H) with an affinity constant of 19.1 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested) . 4.Recombinant Human IL-23 Receptor Protein, hFc Tag (Cat. No. 13840-H02H) captured on Protein A chip can bind Recombinant Human IL-23 Protein, His Tag (Cat. No. CT048-H08H) with an affinity constant of 0.550 nM as determined in an SPR assay (Biacore 8K) (Routinely tested) . 5.Recombinant Human IL-23 Receptor Protein, hFc Tag (Cat. No. 13840-H02H) captured on Protein A chip can bind Amine-Labeled Biotinylated Recombinant Human IL-23 Protein, His Tag (Cat. No. CT048-H08H-B) with an affinity constant of 1.260 nM as determined in an SPR assay (Biacore 8K) (Routinely tested) . 6.Recombinant Human IL-23 Receptor Protein, hFc Tag (Cat. No. 13840-H02H) captured on Protein A chip can bind Biotinylated Recombinant Human IL-23 Protein, His & AVI Tag (Cat. No. CT048-H27H-B) with an affinity constant of 0.669 nM as determined in an SPR assay (Biacore 8K) (Routinely tested) .

The recombinant human IL23R /Fc is a disulfide-linked homodimer. The reduced monomer comprises 571 amino acids and has a predicted molecular mass of 64.9 kDa. The apparent molecular mass of the protein is approximately 92 kDa in SDS-PAGE under reducing conditions due to glycosylation.