IL21R Protein (C-human IgG1-Fc, Human)

Product Specifications

Abbreviation

IL21R

Synonyms

CD360, IMD56, NILR, UNQ3121/PRO10273

Host

HEK 293

Tag

C-human IgG1-Fc

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Purity

> 90 % as determined by SDS-PAGE.

Bioactivity

1.Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 40-200 ng/mL in the presence of 2 ng/mL of recombinant human IL21 (Routinely tested) . 2.Immobilized Recombinant Human Interleukin-21 / IL-21 Protein (Cat:GMP-10584-HNAE) at 2μg/mL (100μL/well) can bind Recombinant Human IL-21R / Il21R Protein (Fc Tag) (Cat:11483-H02H), the EC50 is 130-480 ng/mL (QC tested) . 3.Recombinant Human Interleukin-21 / IL-21 Protein (Cat: 10584-HNAE) immobilized on CM5 chip, can bind Recombinant Human IL-21R / IL21R Protein (Fc Tag) (Cat: 11483-H02H) with an affinity constant of 1.030 nM as determined in an SPR assay (Biacore 8K) (Routinely tested) .