HMGB1 Protein (N-human IgG1-Fc, Human)
Product Specifications
Abbreviation
HMGB1
Synonyms
DKFZp686A04236, HMG-1, HMG1, HMG3, SBP-1
Host
HEK 293
Tag
N-human IgG1-Fc
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
≥ 97 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.
Bioactivity
Loaded Biotinylated Recombinant Human RAGE Protein, hFc Tag (Cat. No. 11629-H41H-B) on SA Biosensor, can bind Recombinant Human HMGB1 Protein, hFc Tag (Cat. No. 10326-H01H) with an affinity constant of 0.307 μM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested) .
Function
Met1-Glu215
Molecular Weight
The recombinant human HMGB1/Fc is a disulfide-linked homodimeric protein.The reduced monomer consists of 452 amino acids and has a predictedmolecular mass of 51.5 kDa. As a result of glycosylation, the apparent molecular mass of rhHMGB1/Fc monomer is approximately 55-60 kDa inSDS-PAGE under reducing conditions.
Species
Human
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