FGFR4 Protein (C-human IgG1-Fc, Human)

Product Specifications

Abbreviation

FGFR4

Synonyms

CD334, JTK2, TKF

Host

HEK 293

Tag

C-human IgG1-Fc

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 97 % as determined by SDS-PAGE

Bioactivity

Measured by its ability to inhibit FGF acidic (aFGF / FGF1) dependent proliferation of Balb/c3T3 mouse embryonic fibroblasts. The ED50 for this effect is typically 5-25ng/mL.

Function

Met1-Asp369

Molecular Weight

The recombinant human FGFR4/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 586 amino acids and has a predicted molecular mass of 66 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rh FGFR4/Fc monomer is approximately 100-110 kDa due to glycosylation.