FAS Protein (C-human IgG1-Fc, Human)
Product Specifications
Abbreviation
FAS
Synonyms
ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6
Host
HEK 293
Tag
C-human IgG1-Fc
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 95 % as determined by SDS-PAGE
Bioactivity
Measured by its ability to inhibit Fas Ligand induced apoptosis of Jurkat human acute T cell leukemia cells. The ED50 for this effect is typically 0.3-2 μg/mL in the presence of recombinant human Fas ligand.
Function
Met1-Glu173
Molecular Weight
The recombinant human Fas/Fc chimera is a disulfide-linked homodimeric protein generated after removal of the signal peptide. The reduced monomer consists of 386 amino acids and has a predicted molecular mass of 43.4 kDa. In SDS-PAGE under reducing conditions, the monomer migrates as an approximately 55-60 kDa protein due to glycosylation.
Species
Human
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