ERBB3 Protein (C-human IgG1-Fc, Cynomolgus, Rhesus)

Product Specifications

Abbreviation

ERBB3

Host

HEK 293

Tag

C-human IgG1-Fc

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 90 % as determined by SDS-PAGE

Bioactivity

Measured by its binding ability in a functional ELISA. Immobilized Human NRG1 Alpha His (Cat:13499-H08H) at 2 μg/ml (100 μl/well) can bind Rhesus HER3/ERBB3 hFc (Cat:90043-K02H), the EC50 of Rhesus HER3/ERBB3 hFc is 250-800 ng/mL.

Function

Met1-Thr643

Molecular Weight

The recombinant Cynomolgus / Rhesus ErbB3/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 865 amino acids and predicts a molecular mass of 95.7 kDa. As a result of glycosylation, rhesus ErbB3/Fc monomer migrates as an approximately 130-140 kDa band in SDS-PAGE under reducing conditions.