ERBB2 Protein (C-mouse IgG1-Fc, Human)

Product Specifications

Abbreviation

ERBB2

Synonyms

C-ERB-2, c-ERB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, MLN19, NEU, NGL, p185 (erbB2), TKR1, VSCN2

Host

HEK 293

Tag

C-mouse IgG1-Fc

Endotoxin

< 1.0 EU per μg protein as determined by the LAL method.

Purity

> 95 % as determined by SDS-PAGE. > 90 % as determined by SEC-HPLC.

Bioactivity

1.Immobilized Recombinant Human Her2/ERBB2 Protein (ECD, mFc Tag) (Cat:10004-H05H) at 2 μg/ml (100 μl/well) can bind Trastuzumab derived Anti-Erbb2 antibody, Human IgG1, the EC50 is 12-36 ng/mL (QC tested) . 2.Immobilized Recombinant Human Her2/ERBB2 Protein (ECD, mFc Tag) (Cat: 10004-H05H) at 0.05 μg/mL (100 μL/well) can bind Pertuzumab derived Anti-Erbb2 antibody, Human IgG1, the EC50 is 7.0-21.0 ng/mL (Routinely tested) .

Function

Met1-Thr652

Molecular Weight

The recombinant human ERBB2 consists of 864 amino acids and predicts a molecular mass of 95.75 kDa.It migrates as an approximately 120.60 KDa band in SDS-PAGE under reducing conditions.