ERBB2 Protein (C-His, Human)
Product Specifications
Abbreviation
ERBB2
Synonyms
C-ERB-2, c-ERB2, CD340, HER-2, HER-2/neu, HER2, MLN 19, MLN-19, MLN19, NEU, NGL, p185 (erbB2), TKR1, VSCN2
Host
HEK 293
Tag
C-His
Endotoxin
< 0.5 EU per mg protein.
Purity
≥ 90 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC. ≥ 90 % as determined by SEC-MALS (Routinely tested) .
Bioactivity
1.Immobilized Recombinant Human HER2 / ErbB2 Protein (His Tag) (Cat: 10004-H08H-UE) at 2 μg/mL (100 μL/well) can bind Anti-HER2 (Research Grade Trastuzu * mab Biosimilar), the EC50 is 5-15 ng/mL (Routinely tested) . 2.Loaded Anti-HER2 (Research Grade Pertuzumab Biosimilar) on proA Biosensor, can bind Recombinant Human HER2 / ErbB2 Protein (His Tag) (Cat. No. 10004-H08H-UE) with an affinity constant of 2.29 nM as determined in BLI assay (Sartorius Octet RED384) (Routinely tested) .
Function
Met 1-Thr 652
Molecular Weight
The recombinant human ErbB2 comprises 641 amino acids and has a calculated molecular mass of 71 kDa. As a result of glycosylation, the band migrates approximately 80-100 kDa in the SDS-PAGE under reducing conditions. The molecular weight of this protein is around 86.7 kDa verified by SEC-MALS (Routinely tested) .
Species
Human
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