EGFR Protein (C-human IgG1-Fc, Human)
Product Specifications
Abbreviation
EGFR
Synonyms
ERBB, ERBB1, ERRP, HER1, mENA, NISBD2, PIG61
Host
HEK 293
Tag
C-human IgG1-Fc
Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method
Purity
> 97 % as determined by SDS-PAGE. >85% as determined by SEC-HPLC
Bioactivity
1.Immobilized Recombinant Human TGFA / TGF-alpha Protein (Cat: 11252-HNAE) at 2 μg/ml (100 μl/well) can bind Recombinant Human EGFR / HER1 / ErbB1 Protein (Fc Tag) (Cat: 10001-H02H), the EC50 is 2-8 ng/mL. 2.Immobilized Recombinant Human EGFR / HER1 / ErbB1 Protein (Fc Tag) (Cat: 10001-H02H) at 1 μg/mL (100 μL/well) can bind Cetuximab derived Anti-EGFR Antibody, Human IgG1, Biotinylated, the EC50 is 12-36 ng/mL (Routinely tested) . 3.Immobilized Recombinant Human EGFR / HER1 / ErbB1 Protein (Fc Tag) (Cat: 10001-H02H) at 2 μg/mL (100 μL/well) can bind Recombinant Human EGF/Epidermal Growth Factor Protein (Fc Tag), Biotinylated (Cat: 10605-H01H-B), the EC50 is 150-450 ng/mL (Routinely tested) .
Function
Met1-Ser645
Molecular Weight
The recombinant human EGFR/Fc chimera is a homodimeric protein. The reduced monomer consists of 860 amino acids and has a calculated molecular mass of 95 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 110-140 kDa protein in SDS-PAGE under reducing conditions.
Species
Human
Curated Selection
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