CSF1R Protein (C-cleavage, Human)

Product Specifications

Abbreviation

CSF1R

Synonyms

BANDDOS, C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, GPSC, HDLS, HDLS1, M-CSF-R

Host

HEK 293

Tag

C-cleavage

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 90 % as determined by SDS-PAGE

Bioactivity

1. Immobilized sMCSFR at 10 μg/ml (100 μl/well) can bind biotinylated human CSF1-His (Cat:11792-H08H), The EC50 of biotinylated human CSF1-His (Cat:11792-H08H) is 32-74.8 ng/ml. 2. Measured by its ability to inhibit the human CSF-induced proliferation of M‐NFS‐60 mouse myelogenous leukemia lymphoblast cells. The ED50 for this effect is typically 0.3-1.5 μg/mL in the presence of 3 ng/mL of rhM-CSF.

Function

Met1-Glu512

Molecular Weight

The recombinant mature human M-CSF R comprises 499 amino acids with a calculated molecular mass of 55.1 kDa. Due to glycosylation, the apparent molecular mass of rhM-CSFR is approximately 80-90 kDa in SDS-PAGE under reducing conditions.