β-Eudesmol

β-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. β-Eudesmol is a neostigmine antagonist. β-Eudesmol can antagonize neostigmine-induced neuromuscular failure. β-Eudesmoll can be used in the study of sepsis diseases. β-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea[1][2][3][4].

Product Specifications

CAS Number

[473-15-4]

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Caspase; Reactive Oxygen Species (ROS) ; SOD; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/beta-eudesmol.html

Purity

99.49

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

C[C@]12[C@@](C(CCC2)=C)([H])C[C@H](C(C)(O)C)CC1

Molecular Formula

C15H26O

Molecular Weight

222.37

Precautions

H302, H315, H319, H335

References & Citations

[1]Ma EL, et al. Beta-eudesmol suppresses tumour growth through inhibition of tumour neovascularisation and tumour cell proliferation. J Asian Nat Prod Res. 2008 Jan-Feb;10 (1-2) :159-67.|[2] Xu Q, et al. Protective effects of β-eudesmol against septic liver injury via inhibition of NF-κB signaling[J]. Tropical Journal of Pharmaceutical Research, 2022, 21 (6) : 1183-1188.|[3]Chiou LC, et al. Antagonism by beta-eudesmol of neostigmine-induced neuromuscular failure in mouse diaphragms. Eur J Pharmacol. 1992 Jun 5;216 (2) :199-206.|[4]Hoang D M, et al. Eudesmols induce apoptosis through release of cytochrome c in HL-60 cells[J]. Natural Product Sciences, 2010, 16 (2) : 88-92.