BMPR1A Protein (C-human IgG1-Fc & His, Mouse)

Product Specifications

Abbreviation

BMPR1A

Synonyms

1110037I22Rik, Acvrlk3, ALK-3, ALK3, Bmpr, BMPR-1A, BMPR-IA, Bmpr1a, SKR5

Host

HEK 293

Tag

C-human IgG1-Fc & His

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 95 % as determined by SDS-PAGE

Bioactivity

Measured by its ability to inhibit BMP4-induced activity in MC3T3-E1 Mouse osteoblastic cells. The ED50 for this effect is typically 0.1-0.3 μg/ml in the presence of 50 ng/mL of recombinant human BMP4.

Function

Met1-Arg152

Molecular Weight

The recombinant mouse ALK3/Fc is a disulfide-linked homodimer after removal of the signal peptide. The reduced monomer consists of 376 amino acids and has a predicted molecular mass of 42 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rm ALK3/Fc monomer is approximately 60 kDa due to glycosylation.