BACE1 Protein (C-human IgG1-Fc, Human)

Product Specifications

Abbreviation

BACE1

Synonyms

ASP2, BACE, HSPC104, KIAA1149

Host

HEK 293

Tag

C-human IgG1-Fc

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 90 % as determined by SDS-PAGE

Bioactivity

Measured by its ability to cleave a fluorogenic peptide substrate, Mca-SEVNLDAEFRK (Dpn) RR-NH2, (R&D Systems, Catalog # ES004) . The specific activity is >0.5 pmoles/min/μg.

Function

Met1-Thr457

Molecular Weight

The recombinant human BACE1/Fc is a disulfide-linked homodimeric protein. The reduced monomer consists of 674 amino acids and has a calculated molecular mass of 75 kDa. As a result of glycosylation, the rhBACE1/Fc monomer migrates as an approximately 100-105 kDa protein in SDS-PAGE under reducing conditions.