AGER Protein (C-human IgG1-Fc, Human)

Product Specifications

Abbreviation

AGER

Synonyms

RAGE, SCARJ1, sRAGE

Host

HEK 293

Tag

C-human IgG1-Fc

Endotoxin

< 1.0 EU per μg of the protein as determined by the LAL method

Purity

> 70 % as determined by SDS-PAGE

Bioactivity

Measured by its binding ability in a functional ELISA. Immobilized human S100A12 at 2 μg/ml (100 μl/well) can bind recombinant human AGER with a linear range of 0.032-20 μg/ml.

Function

Met1-Ala344

Molecular Weight

The recombinant human AGER/Fc chimera is a disulfide-linked homodimeric protein. The reduced monomer consists of 562 amino acids and predictes a molecular mass of 61.1 kDa. In SDS-PAGE under reducing conditions, the apparent molecular mass of rhAGER/Fc monomer is approximately 80-90 kDa due to glycosylation.